The Python is only fully used by Mason in the mission Victor Charliein clearing a Vietcong tunnel with the Flashlight attachment. The flashlight is held similar to the manner to the Tactical Knife in Call of Duty: Modern Warfare 2. It is the secondary weapon in the mission "Executive Order" and is used in the mission "SOG" to shoot theNVA who is about to kill Woods.
Later on it is used by Vietcong troops in a game of Russian roulettebetween Mason and Woods. Mason, gambling the next shot is in the gun, uses it against one of his captors and kills him.
The Python is unlocked at level 18. It has the highest maximum and minimum damage of all the handguns in multiplayer, making it highly effective. It is able to kill in 2 shots at close range and 4 at long range. In Hardcore modes, it is by far the most effective hand gun as it is a one shot kill at any range. The main disadvantages of this weapon are the low six round capacity, high visual recoil, and a long reload time (without a Speed Reloader and/or Sleight of Hand).
The Python is a one-hit kill from round 1-10, after that it becomes a two-three hit kill to the chest .
When the Python is put in the Pack-a-Punch Machine, it becomes the "Cobra", which gives it 12 shots per cylinder and the Speed Reloader attachment. It is a 1 hit kill until round 16.