The RPG-7 returns in Call of Duty: Modern Warfare 2. It is used by the OpFor, Brazilian Militia, and Russian Army in single player, and is available in Special Ops. The RPG has different skins in the campaign, ranging from normal, tan color to white in the snowy missions. In multiplayer, it is the last launcher unlocked and is one of the three that come with two shots. It is unlocked at Level 65. The RPG-7 remains extremely inaccurate at long ranges, where it tends to curve off course, usually upwards, though it is still far more accurate than it used to be in Call of Duty 4. One way to compensate for the inaccuracy of the weapon is to simply crouch. A major advantage with the RPG-7 in Multiplayer is, since it's an unguided rocket, flares from killstreak aircraft will not affect the projectile. On the downside, the RPG-7, like the AT4, does not inflict as much damage to aircraft as compared to the other launchers, with many aircraft able to survive a direct hit from one.

The RPG-7 can only be fired via its rather bulky iron sights and cannot be fired from the hip, unless playing the Museum bonus level. It appears to have a very slight delay between pushing the fire button and the rocket actually firing. Because it travels generally in a straight line, the RPG-7 handles quite differently from the Thumper or the under-barrel launchers, which fire grenades in a ballistic trajectory. Instead of aiming directly at an enemy soldier, it is most effectively fired at a wall, the ground, or a ceiling near the enemy allowing the splash damage to kill the target.

While the RPG-7 can strike helicopters, harriers and other airborne targets and the unguided projectile obviously won't track countermeasures, it lacks the power to bring down some targets in a single shot. The only air vehicles that the RPG-7 can take down in one shot is the UAV, Little Bird and Counter UAV, all of which fly very high and are very small or fast, making them hard to hit. Players looking for an anti-air weapon would do better with the Stinger.

The RPG-7 appears as the RPG in Call of Duty: Black Ops. The crosshair remains the same as it was in Modern Warfare 2, as do the iron sights. The RPG comes with a rocket in the chamber and another reloadable rocket (2 total). However, if the tier one perkScavenger is upgraded to the Pro version, which spawns the player with increased ammunition with their weapons, the RPG will start with one in the chamber and two reloadable rockets (3 total). The RPG on Call of Duty: Black Ops packs less damage than the RPG in other Call of duty games, especially with the reappearance of Flak Jacket.

Trivia

• In Modern Warfare 2, before the 'Javelin glitch' patch, when the user held a Semtex and swapped back to their rocket launcher, a glitch would occur. Instead of immediately exploding, as with all launchers (excluding the Thumper) the rocket would hover in one spot for about a minute before exploding. Players new to this would end up staring at the floating object and be easy picking for a sniper, or after the allotted time, killed by the explosion.
• Sometimes, there will be a glitch in which even though the weapon is out of ammo, a rocket can still be seen in the barrel when it is placed on the ground.
• In MW and MW2, when viewing the RPG in Killcam, (particularly if you shot an RPG, died, and are then watching the killcam) any smoke trails left by the rocket are present before the rocket has been fired; as if fired previously, before the rocket animation occurs.
• Just like the M203 Grenade Launcher, in real life the RPG-7 has a preset safety distance before it will arm the grenade, this distance is usually 10-20 meters (32-65 feet) depending on the type of grenade used; therefore realistically it shouldn't be possible to kill yourself by shooting an RPG-7 into the ground, or nearby wall, within the game.
• When looking at another player firing it, the player can notice that the RPG's grenade doesn't leave the gun when fired.