The map features many alleyways that serve as choke-points, as well as large open streets where combat is more ranged and spread out. A large central apartment building serves as the focus of most of the combat, both within its lower section at the rooms and long hallway above. Portions of other outside structures serve to foil the middle apartment building, offering various positions to shoot in on opponents. This map is most suitable to Assault classes since the range varies from very close combat inside to much more ranged combat in the streets outside. There are enough enclosed spaces however to permit dedicated CQB classes. Snipers will find themselves with more limited options than some larger maps such as Derail.
LMGs are less used than Assault Rifles or SMGs, as they provide poor movement speed combined with slow ADS, and this can be costly in the close quarters battles which are prominent in Skidrow. However, the stairs at the end of the corridor at B in Domination can help an LMG user with a high power weapon such as an RPD, L86 LSW or AUG HBAR in holding the flag, or Spawn Trapping enemies at the flag, as the LMGs can provide long periods of suppressing fire down the hallway.
Sniper Rifles are likely to go unused on this map, however it does feature some well-defensible sniping positions. For example, as mentioned above, the long hallway with the stairs at one end can be used to rack up many kills with a sniper rifle. The building adjacent to the main apartment block (With Objective B in Search and Destroy) can be used to pick off enemies that are either attempting to plant or defuse a bomb planted there. At the other end of the map, there is a commonly camped-in building with a small hole in the wall which overlooks A in Domination, as well as the long alleyway; this provides an excellent sniping position as it is very difficult for enemies to enter the area when overwatched by a good sniper.
Again, due to the close quarters engagements that are dominant in the map, secondary Shotguns are very useful, and very commonly used. A player using a SPAS-12 or another powerful shotgun such as the M1014 can be devastating against enemies using other weapons in close range. Rangers are less useful due to their smaller range, but are good for waiting for an enemy coming round a corner.
Killstreak Rewards, especially the AC-130 and Chopper Gunner are generally ineffective on this map unless the enemy is spawn trapped at the outdoor flag in Domination, or on the Attacking Side in Demolition. This is because most spawns are located indoors and there are few ways a killstreak reward that is airborne will have much use. Therefore, UAVs and Counter-UAVs are incredibly useful as it disorientates enemies due to the multi-leveled fighting seen indoors, or will expose flankers Rushing down the alleys at the sides. Sentry Guns are very useful for defending flags or positioned at choke-points, so generally the lower killstreak rewards prevail.